Hello Kendall, welcome to the group!
I would start by checking for any damage to either the threads on the lead screw or the ārailsā that the V-wheels ride on. Maybe try loosening the backlash block a bit if you donāt have the self adjusting one with the springs although I donāt think if it was the backlash it would always bind in the same spot but itās worth a shot. Another thing that can happen is if the backlash block is mounted a little crooked it might bind at the end of travel where the lead screw doesnāt have any room to flex. You can back off the mounting screws and jog left and right a bit and then tighten them back up to make sure the block is parallel to the lead screw.
Thatās all I have at the momentā¦ good luck!
EDIT: In this post I go over my method for adjusting the backlash, maybe itās useful to you.